Avaliação do Tópico:
  • 0 Voto(s) - 0 em Média
  • 1
  • 2
  • 3
  • 4
  • 5
best online weed stores california
#1
best online weed stores california

We offer CBD Hemp related products providing the best potencies and purity of Cannabidiol (CBD) products available nationwide. Our mission is to educate and promote natural therapies as part of our approach to optimum health and wellness. We have various products to suit the multiple needs and conditions of our clients.

[Imagem: Buy-Now-Button.png]

===>Delivery of the product to all states of America<===

[Imagem: 15864.png]

"Cannabidiol: Barriers to Research and Potential Medical Benefits"

Mr. Chairman, Ms. Chairwoman, and Members of the Senate Drug Caucus, thank you for inviting the National Institute on Drug Abuse (NIDA), a component of the National Institutes of Health (NIH), to participate in this hearing to share what we know about the biology and the potential therapeutic effects of cannabidiol (CBD), one of the main active chemical compounds found in marijuana. In light of the rapidly evolving interest in the potential use of marijuana and its derivative compounds for medical purposes, it is important to take stock of what we know and do not know about the therapeutic potential of CBD.

[Imagem: 8677186c780fe05a77c0b70071c54df4--pet-tr...mp-oil.jpg]

Background

To date, 23 states and the District of Columbia have passed laws allowing marijuana to be used for a variety of medical conditions. Fifteen additional states have enacted laws intended to allow access to CBD oil and/or high-CBD strains of marijuana. Interest in the potential therapeutic effects of CBD has been growing rapidly, partially in response to media attention surrounding the use of CBD oil in young children with intractable seizure disorders including Dravet syndrome and Lennox-Gastaut syndrome. While there are promising preliminary data, the scientific literature is currently insufficient to either prove or disprove the efficacy and safety of CBD in patients with epilepsy.i and further clinical evaluation is warranted. In addition to epilepsy, the therapeutic potential of CBD is currently being explored for a number of indications including anxiety disorders, substance use disorders, schizophrenia, cancer, pain, inflammatory diseases and others. My testimony will provide an overview of what the science tells us about the therapeutic potential of CBD and of the ongoing research supported by NIH in this area.
CBD Biology and Therapeutic Rationale


[Imagem: 15862.png]

Neuroprotective and Anti-Inflammatory Effects

CBD has also been shown to have neuroprotective properties in cell cultures as well as in animal models of several neurodegenerative diseases, including Alzheimer’s,xii,xiii,xiv stroke,xv glutamate toxicity,xvi multiple sclerosis (MS),xvii Parkinson’s disease,xviii and neurodegeneration caused by alcohol abuse.xix Nabiximols (trade name Sativex), which contains THC and CBD in roughly equal proportions, has been approved throughout most of Europe and in a number of other countries for the treatment of spasticity associated with MS. It has not been approved in the United States, but clinical trials are ongoing, and two recent studies reported that nabiximols reduced the severity of spasticity in MS patients.xx,xxi There have been limited clinical trials to assess the potential efficacy of CBD for the other indications highlighted; however, a recent small double-blind trial in patients with Parkinson’s disease found the CBD improved quality-of-life scores.xxii

Analgesic Effects

There have been multiple clinical trials demonstrating the efficacy of nabiximols on central and peripheral neuropathic pain, rheumatoid arthritis, and cancer pain.xxiii In addition, nabiximols is currently approved in Canada for the treatment of central neuropathic pain in MS and cancer pain unresponsive to opioid therapy. However, the current evidence suggests that the analgesia is mediated by THC and it is unclear whether CBD contributes to the therapeutic effects.xxiv THC alone has been shown to reduce pain;xxv,xxvi we are unaware of clinical studies that have explored the efficacy of CBD alone on pain. However, the anti-inflammatory properties of CBD (discussed above) could be predicted to play a role in the analgesic effects of nabiximols. Recent research has also suggested that cannabinoids and opioids have different mechanisms for reducing pain and that their effects may be additive, which suggests that combination therapies may be developed that may have reduced risks compared to current opioid therapies. However, this work is very preliminary.xxvii

Anti-Tumor Effects

In addition to the research on the use of cannabinoids in palliative treatments for cancer—reducing pain and nausea and in increasing appetite—there are also several pre-clinical reports showing anti-tumor effects of CBD in cell culture and in animal models.xxviii These studies have found reduced cell viability, increased cancer cell death, decreased tumor growth, and inhibition of metastasis (reviewed in McAllister et al, 2015).xxix These effects may be due to the antioxidant and anti-inflammatory effects of CBD;xxx however these findings have not yet been explored in human patients. There are multiple industry sponsored clinical trials underway to begin to test the efficacy of CBD in human cancer patients.

Anti-Psychotic Effects

Marijuana can produce acute psychotic episodes at high doses, and several studies have linked marijuana use to increased risk for chronic psychosis in individuals with specific genetic risk factors. Research suggests that these effects are mediated by THC, and it has been suggested that CBD may mitigate these effects.xxxi There have been a few small-scale clinical trials in which patients with psychotic symptoms were treated with CBD, including case reports of patients with schizophrenia that reported conflicting results; a small case study in patients with Parkinson’s disease with psychosis, which reported positive results; and one small randomized clinical trial reporting clinical improvement in patients with schizophrenia treated with CBD.xxxii Large randomized clinical trials would be needed to fully evaluate the therapeutic potential of CBD for patients with schizophrenia and other forms of psychosis.

[Imagem: Tub_and_Tubes-2.jpg]

A chemical known as CBD is quickly changing the debate over the use ... Buy Marijuana Online | Buy weed Online | Weed for sale | CBD Oil for ...
Elixinol organic Hemp CBD Oil is extracted from specifically bred industrial hemp plants that contain high potency of CBD Cannabidiol.

[Imagem: Visit-Website-Button.png]

Anti-Anxiety Effects

CBD has shown therapeutic efficacy in a range of animal models of anxiety and stress, reducing both behavioral and physiological (e.g., heart rate) measures of stress and anxiety.xxxiii,xxxiv In addition, CBD has shown efficacy in small human laboratory and clinical trials. CBD reduced anxiety in patients with social anxiety subjected to a stressful public speaking task.xxxv In a laboratory protocol designed to model post-traumatic stress disorders, CBD improved “consolidation of extinction learning”, in other words, forgetting of traumatic memories.xxxvi The anxiety-reducing effects of CBD appear to be mediated by alterations in serotonin receptor 1a signaling, although the precise mechanism remains to be elucidated and more research is needed.xxxvii

Efficacy for Treating Substance Use Disorders

Early preclinical findings also suggest that CBD may have therapeutic value as a treatment of substance use disorders. CBD reduced the rewarding effects of morphinexxxviii and reduced cue-induced heroin seekingxxxix in animal models. A few small clinical trials have examined CBD and/or nabiximols (THC/CBD) for the treatment of substance use disorders; however, the available data are not sufficient to draw conclusions. NIDA is supporting multiple ongoing clinical trials in this area.

Safety of CBD

For reasons discussed previously, despite its molecular similarity to THC, CBD only interacts with cannabinoid receptors weakly at very high doses (100 times that of THC),xl and the alterations in thinking and perception caused by THC are not observed with CBD.iii.iv,v The different pharmacological properties of CBD give it a different safety profile from THC.

Research Opportunities and Challenges

This is a critical area for new research. While there is preliminary evidence that CBD may have therapeutic value for a number of conditions, we need to be careful to not get ahead of the evidence. Ninety-five percent of drugs that move from promising preclinical findings to clinical research do not make it to market. The recently announced elimination of the PHS review of non-federally funded research protocols involving marijuana is an important first step to enhance conducting research on marijuana and its components such as CBD. Still, it is important to try to understand the reasons for the lack of well-controlled clinical trials of CBD including: the regulatory requirements associated with doing research with Schedule I substances, including a requirement to demonstrate institutional review board approval; and the lack of CBD that has been produced under the guidance of Current Good Manufacturing Processes (cGMP) – required for testing in human clinical trials – available for researchers. Furthermore, the opportunity to gather important information on clinical outcomes through practical (non-randomized) trials for patients using CBD products available in state marijuana dispensaries is complicated by the variable quality and purity of CBD from these sources.

[Imagem: rBVaHVWvNjGAK654AACi8XPix-s609.jpg]

Ongoing CBD Research

The NIH recognizes the need for additional research on the therapeutic effects of CBD and other cannabinoids, and supports ongoing efforts to reduce barriers to research in this area. NIH is currently supporting a number of studies on the therapeutic effects as well as the health risks of cannabinoids. These include studies of the therapeutic value of CBD for:

Treatment of substance use disorders (opioids, alcohol, cannabis, methamphetamine)
Attenuation of the cognitive deficits caused by THC
Neuropathic pain due to spinal cord injury
Mitigating the impact of cannabis use on risk for schizophrenia
Examination of the potential of CBD as an antiepileptic treatment

It is important to note that NIDA’s mission is focused on drug abuse; studies related to the therapeutic effects of CBD in other areas would be funded by the Institute or Center responsible for that program area. For example, studies related to epilepsy will likely be funded by the National Institute of Neurological Disorders and Stroke or by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, while studies related to schizophrenia will likely be funded by the National Institute on Mental Health.
Conclusion

There is significant preliminary research supporting the potential therapeutic value of CBD, and while it is not yet sufficient to support drug approval, it highlights the need for rigorous clinical research in this area. There are barriers that should be addressed to facilitate more research in this area. We appreciate the opportunity to testify on the potential use of CBD for therapeutic purposes. Thank you again for inviting me here today, and I look forward to any questions you may have.

[Imagem: cbd-capsules.jpg]

Copyright 2017 Natural Alchemist. All Rights Reserved.

* These statements have not been evaluated by the FDA. If you are pregnant, nursing, taking medications, or have a medical condition, consult your physician before using this product. Representations regarding the efficacy and safety of CBD have not been evaluated by the Food and Drug Administration. The FDA only evaluates foods and drugs, not supplements like these products. These products are not intended to diagnose, prevent, treat, or cure any disease. Click here to find evidence of a test, analysis, research, or study describing the benefits, performance or efficacy of CBD based on the expertise of relevant professionals.

Best offer click here

[Imagem: 15863.png]





TAGS:
organic weed killer vinegar epsom salt and dawn
buy cbd oil toronto @ buy weed online reddit nfl streams packers
how to get weed out of your system in a week naturally aspirated
cbd oil benefits pdf reader
hemp seed oil buy online Gallant Alabama # buy hemp seed oil capsules online timer
cbd oil colorado made snacks images
is smoking weed and breastfeeding bad for teeth
buy hemp oil for cancer online support
cbd oil buy Americaulele from hawaii to michigan
buy weed online from store news amazon
buy weed online America dictionary thesaurus
cbd oil colorado grown produce to the mass
buy milkweed plants in sc
buy cbd oil online America dictionary worksheets 2nd
how to get weed out of your system in a week yahoo video
buy cbd concentrate wax dragonball
get a california weed card onlinecalifornia buy weed online
marijuana cbd vs hemp cbd vs cannabis cbd salve
marijuana cbd vs hemp cbd vape oil for sale
cbd hemp oil benefits for pain reliefcbd oil benefits for prostate cancercbd oil benefits for skin
buy cbd vape oil for pain 30 ml equals how many fluid
buy cannabis oil online Americaulele lessons
weed edibles online delivered to mass meaning in marathi
cbd cancer fighting youtube addiction to alcohol
homemade weed killer recipe vinegar
cbd oil benefits Americay
smoking weed while pregnant 2016
Hassan was one of dozens of retailers who got cease-and-desist letters from then-Missouri Attorney General Chris Koster last year, telling him to stop selling it. By creating a formal licensing process to allow stores to develop and sell low-THC oil, Koster said the legislature had also created a prohibition on unlicensed sellers.
alternative medicine shop in downtown Mission in October, he called the Kansas attorney general with a seemingly simple question: Am I allowed to sell hemp oil?

“They have only one word: It’s illegal,” Hassan said.
• When using biodiesel, the polluting parameters have decreased. The use of biodiesel in the unmodified Cummins No. 14 diesel engine resulted in a significant reduction in the amount of unburned hydrocarbons, carbon monoxide and particulate matter. Emissions of nitrogen oxides increased slightly.

As you know, you can not spoil the porridge with oil, however, the hemp seed itself is oily, and adding butter or vegetable oil you need to remember this. Usually it is a tablespoon per serving.
5. As a result, our CBD crystals burn at a much higher temperature than everyone else's. Our CBD can be taken up to a consistent 250 degrees+ without any significant loss of material (1-2% max).?
• Particulate matter. Inhalation of these particles poses a serious danger to human health. Emissions of particulate emissions using biodiesel were 30 percent lower than solid particle emissions when using conventional diesel.

But the U.S. Drug Enforcement Administration classifies all parts of the cannabis plant as a Schedule I controlled substance — subject to the agency’s strictest regulation.
“I’ve been on multiple MS drugs, and none of them are cures,” he said, “and I haven’t found any that help with my pain.”

buy thc edibles online shipped wrecked tarpon
weed killer concentrate drumstick leaves # buy cbd oil in Rattan Oklahoma
cbd effects on pain khalil


colorado weed laws faqs or faq's
buy cbd oil vape additives meaning
buy weed eaters nzymes
goden cbd oil vape pen America 500
where to buy cbd oil in indiana 2016 governor polls
cbd oil for sale Shelbyville Tennessee @ buy thc edibles online shipped legal seafood short
colorado state noxious weed list
how to buy legal weed in washington dchow to buy weed legally in coloradohow to buy weed legally
cbd oil cancer treatment
how to get weed seeds when you 143
buy weed online Americae
buy cbd oil online e liquid with paypal


Pular para Fórum:


Usuários visualizando este tópico: 1 Visitante(s)