Avaliação do Tópico:
  • 0 Voto(s) - 0 em Média
  • 1
  • 2
  • 3
  • 4
  • 5
buy weed online Americaraine women
#1
buy weed online Americaraine women

We offer CBD Hemp related products providing the best potencies and purity of Cannabidiol (CBD) products available nationwide. Our mission is to educate and promote natural therapies as part of our approach to optimum health and wellness. We have various products to suit the multiple needs and conditions of our clients.

[Imagem: Buy-Now-Button.png]

===>Delivery of the product to all states of America<===

[Imagem: 15864.png]

"Cannabidiol: Barriers to Research and Potential Medical Benefits"

Mr. Chairman, Ms. Chairwoman, and Members of the Senate Drug Caucus, thank you for inviting the National Institute on Drug Abuse (NIDA), a component of the National Institutes of Health (NIH), to participate in this hearing to share what we know about the biology and the potential therapeutic effects of cannabidiol (CBD), one of the main active chemical compounds found in marijuana. In light of the rapidly evolving interest in the potential use of marijuana and its derivative compounds for medical purposes, it is important to take stock of what we know and do not know about the therapeutic potential of CBD.

[Imagem: CBD-GEls.jpg]

Background

To date, 23 states and the District of Columbia have passed laws allowing marijuana to be used for a variety of medical conditions. Fifteen additional states have enacted laws intended to allow access to CBD oil and/or high-CBD strains of marijuana. Interest in the potential therapeutic effects of CBD has been growing rapidly, partially in response to media attention surrounding the use of CBD oil in young children with intractable seizure disorders including Dravet syndrome and Lennox-Gastaut syndrome. While there are promising preliminary data, the scientific literature is currently insufficient to either prove or disprove the efficacy and safety of CBD in patients with epilepsy.i and further clinical evaluation is warranted. In addition to epilepsy, the therapeutic potential of CBD is currently being explored for a number of indications including anxiety disorders, substance use disorders, schizophrenia, cancer, pain, inflammatory diseases and others. My testimony will provide an overview of what the science tells us about the therapeutic potential of CBD and of the ongoing research supported by NIH in this area.
CBD Biology and Therapeutic Rationale


[Imagem: 15862.png]

Neuroprotective and Anti-Inflammatory Effects

CBD has also been shown to have neuroprotective properties in cell cultures as well as in animal models of several neurodegenerative diseases, including Alzheimer’s,xii,xiii,xiv stroke,xv glutamate toxicity,xvi multiple sclerosis (MS),xvii Parkinson’s disease,xviii and neurodegeneration caused by alcohol abuse.xix Nabiximols (trade name Sativex), which contains THC and CBD in roughly equal proportions, has been approved throughout most of Europe and in a number of other countries for the treatment of spasticity associated with MS. It has not been approved in the United States, but clinical trials are ongoing, and two recent studies reported that nabiximols reduced the severity of spasticity in MS patients.xx,xxi There have been limited clinical trials to assess the potential efficacy of CBD for the other indications highlighted; however, a recent small double-blind trial in patients with Parkinson’s disease found the CBD improved quality-of-life scores.xxii

Analgesic Effects

There have been multiple clinical trials demonstrating the efficacy of nabiximols on central and peripheral neuropathic pain, rheumatoid arthritis, and cancer pain.xxiii In addition, nabiximols is currently approved in Canada for the treatment of central neuropathic pain in MS and cancer pain unresponsive to opioid therapy. However, the current evidence suggests that the analgesia is mediated by THC and it is unclear whether CBD contributes to the therapeutic effects.xxiv THC alone has been shown to reduce pain;xxv,xxvi we are unaware of clinical studies that have explored the efficacy of CBD alone on pain. However, the anti-inflammatory properties of CBD (discussed above) could be predicted to play a role in the analgesic effects of nabiximols. Recent research has also suggested that cannabinoids and opioids have different mechanisms for reducing pain and that their effects may be additive, which suggests that combination therapies may be developed that may have reduced risks compared to current opioid therapies. However, this work is very preliminary.xxvii

Anti-Tumor Effects

In addition to the research on the use of cannabinoids in palliative treatments for cancer—reducing pain and nausea and in increasing appetite—there are also several pre-clinical reports showing anti-tumor effects of CBD in cell culture and in animal models.xxviii These studies have found reduced cell viability, increased cancer cell death, decreased tumor growth, and inhibition of metastasis (reviewed in McAllister et al, 2015).xxix These effects may be due to the antioxidant and anti-inflammatory effects of CBD;xxx however these findings have not yet been explored in human patients. There are multiple industry sponsored clinical trials underway to begin to test the efficacy of CBD in human cancer patients.

Anti-Psychotic Effects

Marijuana can produce acute psychotic episodes at high doses, and several studies have linked marijuana use to increased risk for chronic psychosis in individuals with specific genetic risk factors. Research suggests that these effects are mediated by THC, and it has been suggested that CBD may mitigate these effects.xxxi There have been a few small-scale clinical trials in which patients with psychotic symptoms were treated with CBD, including case reports of patients with schizophrenia that reported conflicting results; a small case study in patients with Parkinson’s disease with psychosis, which reported positive results; and one small randomized clinical trial reporting clinical improvement in patients with schizophrenia treated with CBD.xxxii Large randomized clinical trials would be needed to fully evaluate the therapeutic potential of CBD for patients with schizophrenia and other forms of psychosis.

[Imagem: 25pk-3.jpg?v=1490163103]

4 Corners Cannabis is the home of CBD products in Colorado. We offer CBD tinctures, CBD Vape liquid, CBD Salve. Find out why we have the best CBD Oil ...
CBD Hemp Oil- 100 MG. This product been shown to help with anxiety, Epilepsy, pain, and many other health ailments.

[Imagem: Visit-Website-Button.png]

Anti-Anxiety Effects

CBD has shown therapeutic efficacy in a range of animal models of anxiety and stress, reducing both behavioral and physiological (e.g., heart rate) measures of stress and anxiety.xxxiii,xxxiv In addition, CBD has shown efficacy in small human laboratory and clinical trials. CBD reduced anxiety in patients with social anxiety subjected to a stressful public speaking task.xxxv In a laboratory protocol designed to model post-traumatic stress disorders, CBD improved “consolidation of extinction learning”, in other words, forgetting of traumatic memories.xxxvi The anxiety-reducing effects of CBD appear to be mediated by alterations in serotonin receptor 1a signaling, although the precise mechanism remains to be elucidated and more research is needed.xxxvii

Efficacy for Treating Substance Use Disorders

Early preclinical findings also suggest that CBD may have therapeutic value as a treatment of substance use disorders. CBD reduced the rewarding effects of morphinexxxviii and reduced cue-induced heroin seekingxxxix in animal models. A few small clinical trials have examined CBD and/or nabiximols (THC/CBD) for the treatment of substance use disorders; however, the available data are not sufficient to draw conclusions. NIDA is supporting multiple ongoing clinical trials in this area.

Safety of CBD

For reasons discussed previously, despite its molecular similarity to THC, CBD only interacts with cannabinoid receptors weakly at very high doses (100 times that of THC),xl and the alterations in thinking and perception caused by THC are not observed with CBD.iii.iv,v The different pharmacological properties of CBD give it a different safety profile from THC.

Research Opportunities and Challenges

This is a critical area for new research. While there is preliminary evidence that CBD may have therapeutic value for a number of conditions, we need to be careful to not get ahead of the evidence. Ninety-five percent of drugs that move from promising preclinical findings to clinical research do not make it to market. The recently announced elimination of the PHS review of non-federally funded research protocols involving marijuana is an important first step to enhance conducting research on marijuana and its components such as CBD. Still, it is important to try to understand the reasons for the lack of well-controlled clinical trials of CBD including: the regulatory requirements associated with doing research with Schedule I substances, including a requirement to demonstrate institutional review board approval; and the lack of CBD that has been produced under the guidance of Current Good Manufacturing Processes (cGMP) – required for testing in human clinical trials – available for researchers. Furthermore, the opportunity to gather important information on clinical outcomes through practical (non-randomized) trials for patients using CBD products available in state marijuana dispensaries is complicated by the variable quality and purity of CBD from these sources.

[Imagem: vape-pen.jpg]

Ongoing CBD Research

The NIH recognizes the need for additional research on the therapeutic effects of CBD and other cannabinoids, and supports ongoing efforts to reduce barriers to research in this area. NIH is currently supporting a number of studies on the therapeutic effects as well as the health risks of cannabinoids. These include studies of the therapeutic value of CBD for:

Treatment of substance use disorders (opioids, alcohol, cannabis, methamphetamine)
Attenuation of the cognitive deficits caused by THC
Neuropathic pain due to spinal cord injury
Mitigating the impact of cannabis use on risk for schizophrenia
Examination of the potential of CBD as an antiepileptic treatment

It is important to note that NIDA’s mission is focused on drug abuse; studies related to the therapeutic effects of CBD in other areas would be funded by the Institute or Center responsible for that program area. For example, studies related to epilepsy will likely be funded by the National Institute of Neurological Disorders and Stroke or by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, while studies related to schizophrenia will likely be funded by the National Institute on Mental Health.
Conclusion

There is significant preliminary research supporting the potential therapeutic value of CBD, and while it is not yet sufficient to support drug approval, it highlights the need for rigorous clinical research in this area. There are barriers that should be addressed to facilitate more research in this area. We appreciate the opportunity to testify on the potential use of CBD for therapeutic purposes. Thank you again for inviting me here today, and I look forward to any questions you may have.

[Imagem: cbd-hemp-oil-vaporizers.jpg]

Copyright 2017 Natural Alchemist. All Rights Reserved.

* These statements have not been evaluated by the FDA. If you are pregnant, nursing, taking medications, or have a medical condition, consult your physician before using this product. Representations regarding the efficacy and safety of CBD have not been evaluated by the Food and Drug Administration. The FDA only evaluates foods and drugs, not supplements like these products. These products are not intended to diagnose, prevent, treat, or cure any disease. Click here to find evidence of a test, analysis, research, or study describing the benefits, performance or efficacy of CBD based on the expertise of relevant professionals.

Best offer click here

[Imagem: 15863.png]





TAGS:
smoking weed and breastfeeding infants
rihanna smoking CBD hemp oil gif
cbd oil for sale Sturgis South Dakota @ where to buy cbd oil for cancer treatment in texaswhere to buy cbd oil for pain and how stronge
hemp seed oil buy online Spanish Fort Alabama @ online weed dealing games of thrones
cbd oil to buy Parma Missouri @ cbd oil effects high cortisol
buy weed seeds online from amsterdambuy weed online from california
buy organic cbd oil America
homemade weed killer vinegar epsom salt dawn soap kills ants
colorado weed price 2016 chevy trucks
homemade weed killer epsom salt vinegar dawn
cbd benefits flyers skate
cbd oil for cervical cancer treatment
cbd oil vape info graphics free
cbd oil where to buy near me pizza
benefits of cbd oil for breast cancer
cbd oil America law 2016 us governors election
how long to get weed out of your system after smoking once
how long does it take to feel the effects of cbd oilhow long to get weed out of my system
buy hemp oil phoenix tears hempstead
is smoking weed and driving dangerous movie titles
buy weed online Americae lessons strumming
cheap marijuana pipes for sale
thc cbd online attijari net tunisie numérique
best cbd oil to buy for cancer
where to buy cannabis oil cbd & thc cells
marijuana cbd thc thca cbda oil
smoking weed while pregnant results with very slight chest
That’s more direction than Kansas Attorney General Derek Schmidt was able to provide.
Brewing cannabis porridge is very simple. Cannabis seeds must be soaked for several hours in cold water before cooking. This preparatory procedure significantly shortens the period of cooking porridge, and, therefore, reduces the damaging effect of heat treatment on the vitamin range. For this, about 2 cups of water are taken on a glass of cereal. To avoid evaporation of moisture, the soaked croup is covered with a lid.

Cannabidiol (CBD) is 100% legal to buy and sell in Statesville North-Carolina now.
• The smog volume at burning of biodiesel fuel is less, than at diesel fuel. The ozone-generating potential of hydrocarbon emissions was approximately 50 percent lower than the similar potential with diesel fuel.

As both a veterinary herbalist and acupuncturist and skilled in the use of natural medicines Dr. Silver has written this important book for your pet in easy-to-understand language, with an included glossary of the more technical terms. We are honored to be working with Dr. Silver and we can provide a free consultation on bulk CBD for pet formulations and which of our bulk and wholesale CBD oils for pets, wholesale CBD pills for pets, CBD powders and CBD liquids can be used effectively to supply your brand or company with the very best hemp-derived cannabidiol (CBD) formulations for pets in the world!"MEDICAL MARIJUANA AND YOUR PETS" Dr. Rob Silver proudly announces that his long-awaited book on the use of medical marijuana and pets is now available in three eBook formats for immediate download, or a print book hard copy with 146 pages and 36 color
Most minds reject even attempting to calculate the expansive numbers of building athletes on an annual basis... and with good reason. Football is still America's most active pastime in Statesville North-Carolina - with over 1,088,000 participants in the sport from pee wee to professional. But outdoor track and field, basketball, soccer, baseball, volleyball, cross-country, tennis, and swimming are close on its heels. Many sports run almost neck-in-neck in gender participation while volleyball, tennis, and swimming are dominated by females. Still, regardless of how much training a player has, a simple accident can lead to a lifetime of pain, suffering, and even early permanent retirement from the activity. But that doesn't necessarily have to happen. In fact, science has recently discovered a link between athletic healing and CBD (Cannabidiol). But can cannabis really be the key to protecting and healing over seven million American athletes? First of All, What is CBD? The use of medical marijuana is a relatively new debate, especially considering cannabis is one of the oldest medicinal herbs known. In fact, religions and science alike can trace its use back to ancient times for both recreational and medicinal use. Yet, for over a century, scientists have focused solely on the negative aspects of the plant. The shift in Western society is so new that it's taken media stage and confused a slew of people in the process. But the truth is, cannabis has always been beneficial for medicinal needs. Science just needed to narrow those findings down to meet political expectations.
Chemical composition:Linoleic acid - 55% Linolenic acid - 20% Oleic acid is 11% Palmitic acid - 6% Stearic acid2.5% Palmitolenic acid - 0.15% Action: Hemp oil has excellent nutritional, protective and regenerating properties. It returns softness and elasticity to the skin, effectively fights with dehydration, thanks to its ability to retain moisture in the skin. Has a high penetrating ability, absorbs quickly and without greasy shine, perfectly restores the texture of the skin. It also strengthens the walls of the capillaries and has an anti-corrosive effect. Effectively protects the skin from premature aging, thanks to its ability to bind free radicals. Also, hemp oil has a good cosmetic effect on the hair condition: nourishes the capillary fiber, improves the structure of the hair, gives them extra shine, flexibility, volume and facilitates stacking.

The most famous two types of cannabis are cannabis herb (normal) - Cannobis sativa L., used to produce fiber and seeds, and hemp Indian (hashish) - Cannobis indica Lam, which is cultivated for the production of leaves from drugs. Cultivated in India, Iran, Turkey and other countries.
Other businesses were less compliant.

smoking CBD hemp oil causes cancer
natural CBD hemp oil killer recipe for lawns
best weed smoking quotes that rhyme with 2017


how to buy cbd oil in michigan 2016 presidential results michigan
buy cheap cbd isolate powdercheap cbd oil America applications
colorado weed price 2016 chevy trucks
smoking CBD hemp oil while pregnant meme
cannabis oil cbd buy for vape pen
cbd oil benefits mmn disease wikipedia indonesia # where to buy cbd products in Valley Center California
buy cbd vape oil for pain 30 ml = tsp
where to buy cbd oil with thc for pain
buy cannabis concentrates definition of socialism
marijuana cbd meaning cannabis sativa oil
scotts weed killer for lawns reviews of bio
cheap high tea melbourne cbd accommodation meaning in science


Pular para Fórum:


Usuários visualizando este tópico: 1 Visitante(s)